Surface Modulation of CuS Quantum Dots using Biginelli Compounds for Construction of a Portable Fluorescence Sensor for Bacteria

Surface Modulation of CuS Quantum Dots using Biginelli Compounds for Construction of a Portable Fluorescence Sensor for BacteriaPublic Health

ABOUT THE PROJECT

The project proposes to develop a fluorescent quantum dots (QDs) based biosensor for detection bacteria, which represents a next generation ion the field of bacteria detection. Bacterial strains of Salmonella, E. coli, L. pneumophila, Shigella, and Staphylococcus which are responsible for gastrointestinal or enteric diseases will be investigated. Modified (biginelli derivatives/Ab) QDs will be deposited on screen printed electrodes

RESEARCH ABSTRACT

Bacterial infection in human is a common and ancient disease that causes serious health illness.1– 3 Due to contaminant water and use of pesticides in food production, bacterial infection increases day by day while anti-bacterial drugs cause serious side effects such as diarrhea, rash, abdominal pain and vomiting etc.4 To avoid such kind of side effects, it is also important to analyses food, and processed eatables. For clinical test, selective bacteria sensor is need of today to simplify the procedure of analysing the diseases. Furthermore, distinguishing the bacterial and viral infections is a complicating task.5,6 Various reports are available on bacteria sensing, however complexity of procedures, cost of methodology, and scientific analysis of data and reproducibility of results demand a simple, portable, cost effective and reproducible technique. In last five years, there is a landmark development in fluorescence based sensors for biomolecules detection. In this project, we are proposing a fluorescent quantum dots (QDs) based biosensor for detection of bacteria, which represents a next generation in the field of bacteria detection. Coating of QD7–9 with biginelli and biginelli derivatives will allow binding simultaneously both QDs and antibody (Ab). We will investigate bacterial strains of Salmonella, E. coli, L. pneumophila, Shigella, and Staphylococcus) that are responsible for gastrointestinal or enteric diseases in whole World. The modified (biginelli derivatives/Ab) QDs will be deposited on screen printed electrodes.